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|
Systolic blood pressure changes (mmHg)
|
|---|
| |
High-response group
|
Low-response group
|
|---|
| |
Mean blood pressure
|
SEM
|
Mean blood pressure
|
SEM
|
|---|
| |
Caffeine
|
L-theanine
|
Placebo
|
Caffeine
|
L-theanine
|
Placebo
|
Caffeine
|
L-theanine
|
Placebo
|
Caffeine
|
L-theanine
|
Placebo
|
|---|
|
Base
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
|
AMT1
|
4.83
|
7.17
|
12.17
|
5.75
|
4.85
|
3.58
|
10.32
|
5.78
|
6.82
|
3.02
|
7.25
|
3.12
|
|
AMT2
|
3.05
|
5.55
|
13.82
|
3.48
|
6.04
|
3.48
|
5.62
|
2.07
|
1.36
|
3.84
|
5.23
|
2.06
|
|
AMT3
|
5.10
|
−0.36
|
17.68
|
2.95
|
8.50
|
3.24
|
5.78
|
4.31
|
3.98
|
2.89
|
5.80
|
2.01
|
|
AMT4
|
7.95
|
−0.49
|
21.35
|
3.24
|
5.45
|
3.36
|
5.98
|
9.05
|
3.64
|
5.19
|
4.79
|
2.39
|
|
AMT5
|
8.08
|
2.88
|
21.82
|
3.71
|
2.66
|
5.46
|
6.92
|
9.28
|
2.75
|
4.25
|
5.35
|
2.56
|
|
AMT6
|
10.75
|
5.01
|
22.41
|
3.55
|
2.21
|
4.47
|
5.91
|
9.98
|
3.28
|
4.47
|
5.75
|
2.63
|
|
CPT1
|
5.63
|
4.14
|
15.34
|
5.61
|
3.78
|
7.61
|
−2.63
|
7.00
|
3.19
|
5.17
|
7.55
|
4.03
|
|
CPT2
|
3.98
|
10.10
|
12.74
|
7.04
|
7.37
|
10.28
|
−9.26
|
−2.76
|
3.42
|
5.66
|
6.86
|
5.74
|
|
CPT3
|
18.58
|
28.22
|
19.57
|
7.20
|
5.92
|
8.47
|
3.98
|
12.31
|
15.95
|
5.00
|
7.35
|
4.41
|
|
CPT4
|
29.62
|
36.24
|
28.04
|
8.36
|
8.02
|
7.11
|
16.20
|
23.71
|
25.82
|
4.58
|
5.79
|
3.57
|
|
CPT5
|
40.52
|
47.64
|
40.05
|
8.71
|
6.67
|
4.70
|
31.65
|
32.08
|
33.61
|
5.23
|
7.46
|
4.99
|
|
CPT6
|
45.36
|
54.15
|
49.15
|
7.15
|
6.22
|
4.24
|
38.10
|
39.48
|
39.24
|
6.85
|
7.55
|
5.25
|
|
RP1
|
44.70
|
50.71
|
49.64
|
6.61
|
5.76
|
5.98
|
35.92
|
40.74
|
35.55
|
4.57
|
7.75
|
6.34
|
|
RP2
|
43.03
|
43.70
|
46.51
|
7.48
|
6.69
|
6.26
|
35.18
|
43.70
|
36.82
|
5.86
|
7.85
|
6.26
|
|
RP3
|
35.78
|
38.82
|
41.28
|
6.13
|
6.70
|
6.77
|
31.30
|
33.81
|
33.41
|
4.95
|
6.94
|
6.57
|
|
RP4
|
30.66
|
29.77
|
32.61
|
6.63
|
6.02
|
4.00
|
26.18
|
26.68
|
26.41
|
4.76
|
6.68
|
4.66
|
|
RP5
|
25.05
|
24.68
|
24.78
|
6.41
|
5.04
|
2.77
|
24.11
|
20.12
|
21.92
|
4.78
|
5.82
|
4.89
|
|
RP6
|
22.99
|
20.92
|
20.12
|
5.56
|
4.09
|
2.23
|
20.73
|
18.22
|
17.99
|
4.70
|
5.20
|
4.58
|
|
RP7
|
21.68
|
19.58
|
19.90
|
5.15
|
3.96
|
3.03
|
16.51
|
21.51
|
18.14
|
3.77
|
5.38
|
4.31
|
|
RP8
|
19.99
|
16.77
|
21.42
|
5.33
|
3.83
|
2.28
|
15.97
|
19.44
|
17.05
|
4.62
|
5.35
|
2.91
|
|
RP9
|
18.95
|
14.82
|
23.78
|
4.52
|
3.25
|
2.61
|
15.17
|
17.75
|
18.78
|
4.82
|
5.95
|
3.62
|
|
RP10
|
15.32
|
15.12
|
20.72
|
3.46
|
3.71
|
3.11
|
13.72
|
18.22
|
20.75
|
5.11
|
6.80
|
3.90
|
|
RP11
|
15.72
|
16.94
|
17.67
|
3.20
|
5.49
|
3.23
|
15.27
|
18.48
|
22.31
|
4.22
|
6.66
|
4.34
|
|
RP12
|
17.25
|
17.55
|
19.34
|
3.29
|
3.98
|
3.38
|
17.28
|
18.84
|
21.79
|
4.70
|
6.35
|
4.66
|
|
RP13
|
17.35
|
15.34
|
23.24
|
3.92
|
3.46
|
3.27
|
15.42
|
22.60
|
17.48
|
4.96
|
6.25
|
4.65
|
|
RP14
|
15.36
|
16.77
|
20.18
|
3.67
|
5.27
|
3.30
|
14.40
|
18.04
|
15.75
|
5.45
|
5.50
|
3.33
|
|
RP15
|
15.06
|
18.07
|
22.38
|
3.85
|
3.84
|
2.66
|
9.80
|
20.72
|
15.35
|
5.23
|
6.03
|
3.03
|
|
RP16
|
16.48
|
16.54
|
18.65
|
2.71
|
3.50
|
3.63
|
12.42
|
23.12
|
17.28
|
4.57
|
7.01
|
3.83
|
|
RP17
|
18.10
|
17.70
|
17.67
|
3.75
|
2.96
|
3.49
|
13.92
|
19.35
|
18.24
|
4.87
|
5.63
|
3.76
|
|
RP18
|
18.33
|
16.40
|
15.70
|
3.04
|
1.96
|
4.23
|
14.43
|
16.14
|
19.36
|
3.91
|
6.94
|
3.10
|
|
Diastolic blood pressure changes (mmHg)
|
| |
High-response group
|
Low-response group
|
| |
Mean blood pressure
|
SEM
|
Mean blood pressure
|
SEM
|
| |
Caffeine
|
L-theanine
|
Placebo
|
Caffeine
|
L-theanine
|
Placebo
|
Caffeine
|
L-theanine
|
Placebo
|
Caffeine
|
L-theanine
|
Placebo
|
|
Base
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
|
AMT1
|
4.96
|
6.00
|
11.74
|
3.66
|
2.30
|
1.97
|
7.41
|
5.87
|
7.14
|
2.65
|
3.20
|
1.62
|
|
AMT2
|
4.47
|
5.34
|
12.30
|
2.53
|
1.31
|
3.56
|
2.38
|
1.46
|
4.14
|
2.61
|
2.98
|
2.08
|
|
AMT3
|
5.09
|
0.61
|
12.60
|
1.98
|
3.27
|
2.91
|
3.51
|
3.00
|
4.39
|
2.71
|
3.27
|
2.27
|
|
AMT4
|
5.73
|
2.14
|
17.07
|
2.39
|
2.20
|
2.83
|
4.22
|
5.31
|
5.39
|
3.34
|
3.22
|
2.00
|
|
AMT5
|
5.81
|
5.67
|
16.10
|
2.27
|
3.43
|
4.83
|
5.39
|
4.99
|
4.51
|
2.92
|
3.03
|
1.88
|
|
AMT6
|
7.19
|
6.64
|
16.90
|
2.37
|
3.08
|
3.73
|
3.95
|
6.66
|
4.64
|
2.98
|
3.03
|
1.73
|
|
CPT1
|
7.70
|
7.64
|
18.30
|
3.54
|
3.66
|
4.12
|
3.16
|
10.21
|
7.52
|
4.15
|
3.32
|
2.35
|
|
CPT2
|
8.56
|
9.58
|
16.31
|
3.87
|
3.60
|
5.78
|
0.89
|
1.36
|
6.49
|
4.13
|
3.14
|
2.88
|
|
CPT3
|
20.21
|
22.98
|
22.82
|
4.57
|
4.24
|
3.62
|
9.71
|
11.34
|
16.82
|
3.16
|
3.73
|
1.73
|
|
CPT4
|
28.40
|
30.20
|
29.32
|
5.15
|
6.15
|
1.49
|
18.34
|
20.10
|
23.91
|
2.86
|
2.84
|
2.14
|
|
CPT5
|
36.06
|
38.60
|
38.72
|
5.17
|
5.60
|
2.20
|
24.56
|
26.83
|
28.84
|
2.47
|
3.38
|
1.91
|
|
CPT6
|
39.39
|
42.83
|
43.18
|
4.30
|
4.62
|
3.75
|
27.31
|
30.29
|
32.04
|
2.90
|
3.73
|
2.23
|
|
RP1
|
35.79
|
38.60
|
42.20
|
5.27
|
4.67
|
4.80
|
24.09
|
27.87
|
27.85
|
2.71
|
3.48
|
2.61
|
|
RP2
|
32.09
|
31.23
|
36.65
|
6.64
|
5.16
|
4.47
|
19.93
|
25.49
|
24.41
|
3.35
|
3.74
|
2.22
|
|
RP3
|
25.97
|
26.03
|
31.75
|
5.68
|
5.50
|
4.00
|
16.69
|
18.37
|
19.62
|
3.04
|
3.84
|
3.18
|
|
RP4
|
21.84
|
21.50
|
25.34
|
5.36
|
5.65
|
2.92
|
13.60
|
15.34
|
16.02
|
3.16
|
3.82
|
2.84
|
|
RP5
|
18.16
|
17.67
|
19.81
|
5.31
|
4.85
|
2.57
|
12.40
|
12.10
|
12.68
|
3.04
|
3.10
|
2.99
|
|
RP6
|
16.11
|
15.78
|
16.97
|
4.49
|
4.38
|
1.68
|
10.79
|
11.10
|
11.09
|
3.20
|
2.71
|
2.72
|
|
RP7
|
14.83
|
14.55
|
15.90
|
3.73
|
4.37
|
1.58
|
8.04
|
12.81
|
11.44
|
2.59
|
2.66
|
2.59
|
|
RP8
|
13.71
|
12.40
|
16.55
|
3.80
|
3.67
|
1.98
|
8.26
|
10.90
|
10.98
|
3.29
|
2.75
|
1.79
|
|
RP9
|
12.59
|
12.25
|
18.04
|
3.83
|
3.38
|
2.17
|
6.76
|
10.14
|
12.08
|
3.11
|
2.99
|
2.36
|
|
RP10
|
9.06
|
12.00
|
15.18
|
2.98
|
3.86
|
2.63
|
5.95
|
10.23
|
12.16
|
3.47
|
2.99
|
2.64
|
|
RP11
|
10.23
|
12.78
|
13.37
|
2.58
|
3.72
|
2.73
|
7.45
|
10.24
|
12.82
|
2.42
|
2.62
|
2.38
|
|
RP12
|
10.90
|
12.94
|
14.80
|
2.89
|
3.04
|
2.93
|
7.04
|
10.61
|
12.76
|
3.19
|
3.18
|
2.62
|
|
RP13
|
10.04
|
11.61
|
16.50
|
3.04
|
2.74
|
2.47
|
6.49
|
12.07
|
9.99
|
2.90
|
2.95
|
2.94
|
|
RP14
|
8.90
|
12.14
|
13.94
|
2.90
|
3.26
|
2.53
|
5.72
|
8.90
|
9.75
|
3.19
|
3.04
|
1.67
|
|
RP15
|
9.30
|
12.54
|
16.81
|
3.12
|
2.76
|
1.97
|
4.38
|
11.49
|
8.88
|
3.33
|
2.78
|
1.70
|
|
RP16
|
8.99
|
10.44
|
13.04
|
2.50
|
1.71
|
2.86
|
5.96
|
11.91
|
9.58
|
2.28
|
2.87
|
1.76
|
|
RP17
|
9.30
|
11.80
|
12.77
|
2.69
|
2.30
|
3.38
|
5.79
|
9.37
|
10.08
|
3.29
|
2.70
|
2.12
|
|
RP18
|
9.66
|
12.08
|
10.03
|
2.33
|
2.53
|
3.43
|
6.17
|
8.93
|
11.50
|
2.43
|
3.06
|
2.57
|